Using a new antibiotic called moxifloxacin in combination with other drugs could cut several months off the six months it currently takes to cure patients with drug-treatable tuberculosis, according to a phase 2 study.
Long treatment times can result in patients failing to complete their drug therapy, so a shorter period of treatment could improve patient compliance, the researchers noted. Shorter TB treatment regimens would also reduce the workload for overburdened TB control programs, especially in countries with high TB rates
The study included 170 TB patients treated at a hospital in Rio de Janeiro, Brazil, who were receiving a standard combination of three first-line TB drugs. They were randomly selected to receive as their fourth drug either moxifloxacin 400 milligrams, along with an ethambutol placebo (85 patients), or ethambutol (15-20 mg per kilogram of body weight) plus moxifloxacin placebo (85 patients) five days a week for eight weeks.
The drug ethambutol is widely used in TB treatment but has very little activity and was used as a control in this study.
After eight weeks, 80 percent of patients in the moxifloxacin group tested negative for TB, compared with 63 percent of patients in the ethambutol group. A total of 16 negative events (eight in each group) were reported in 12 patients, but only one of those events was linked to moxifloxacin, according to Dr. Richard E. Chaisson, of the Center for Tuberculosis Research at Johns Hopkins University School of Medicine in Baltimore, and colleagues.
By American Lung Association. April 03, 2009
Many Americans Fear Being Diagnosed With Diabetes
More than half of Americans fear developing diabetes, but many continue the unhealthy behaviors that boost their odds of getting the blood sugar disease, a new survey shows.
"I think people continue the risky behaviors because they think, 'It's not going to happen to me,'" said Dr. Richard M. Bergenstal, president-elect for medicine and science for the American Diabetes Association, which commissioned the survey. "Or, they know they are at risk but they are so ingrained in their daily lifestyle they have not been motivated to change."
The survey, released Tuesday as part of American Diabetes Alert Day, is meant as a "wake-up call" to raise awareness of diabetes and its risk factors.
The poll was conducted online by Harris Interactive in February and early March. More than 2,500 U.S. adults aged 18 and above were polled.
Choosing from a list, 52 percent of respondents said having a chronic illness was the worst thing they could imagine happening. In comparison, just 19 percent said drowning in debt would be the worst thing, while 13 percent cited getting a divorce or living alone, 11 percent cited losing their job and 4 percent said gaining significant weight would be the worst thing.
About half said they haven't talked to their doctor about common chronic diseases such as diabetes, heart disease, cancer, HIV/AIDS or Alzheimer's disease.
Most of those polled knew at least one diabetes risk factor, but fewer than half recognized their own risk factors (such as overweight). And more than half the respondents mistakenly said eating too much sugar was a diabetes risk factor.
While 70 percent of respondents said maintaining an unhealthy weight is risky, 46 percent admitted to being overweight.
And while 66 percent of those who answered said avoiding doctors is risky, 50 percent said they did just that.
"It's pretty amazing, the level of inactivity and poor eating," said Bergenstal, who is also executive director of the International Diabetes Center at Park-Nicollet Health Services in Minneapolis. "Most people most know it's not good for them."
He suspects that some people are in denial, knowing on some level that poor eating habits and a lack of exercise are both unhealthy, but thinking it won't affect them.
"We started doing Diabetes Alert Day 21 years ago," he said. At that time, about 6 million people in the United States had diabetes. "Now, 20 years later, 18 million are diagnosed," he said, with a total of nearly 24 million either diagnosed or suspected to have the condition.
By Kathleen Doheny, HealthDay Reporter. March 24, 2009
Viagra Helps COPD Patients Control Pulmonary Blood Pressure
The drug sildenafil, popularly known as Viagra, may help people with chronic obstructive pulmonary disease control the illness-related blood pressure spikes in the heart's pulmonary artery, a new study found.
The medication, in addition to its use as a popular treatment for impotence, has already been approved by the U.S. Food and Drug Administration for the treatment of the chronic version of such blood pressure spikes, known as pulmonary arterial hypertension (PAH). The drug has been marketed specifically for this purpose under the trade name Revatio. Another drug -- bosentan -- is also approved for similar purposes.
The new research suggests that sildenafil may help all chronic obstructive pulmonary disease (COPD) patients -- even those not diagnosed with full-blown PAH -- who experience potentially dangerous pulmonary arterial blood pressure increases both at rest and following exercise.
The research was led by Dr. Sebastiaan Holverda of the department of pulmonary medicine at VU University Medical Center in Amsterdam, the Netherlands. Holverda and his VU colleagues were to present their findings Wednesday at a Salt Lake City meeting organized by the journal Chest.
According to the American Lung Association, COPD is actually a catch-all for two lung diseases that often strike in tandem -- chronic bronchitis and emphysema. In both cases, airflow is obstructed, impeding normal breathing.
Smoking is the leading cause of COPD, responsible for between 80 percent and 90 percent of all cases in the United States. More than 11 million Americans are estimated to have the illness, and more than 122,000 die from it each year. Women appear to be slightly more at risk than men.
There's no known cure for the disease, and medications primarily take aim at symptom relief and slowing the progressive disability the illness brings.
Pulmonary hypertension -- the incurable condition of continuous high blood pressure in the pulmonary artery located in the right ventricle of the heart -- is one of many serious complications that can strike COPD patients. PAH causes the artery, which is responsible for delivering blood from the heart to the lungs, to work harder than normal. A weakening of the heart muscle can ensue over time, increasing the risk of heart failure and even death.
The Dutch researchers noted that pulmonary hypertension is typically mild to moderate among COPD patients but is particularly aggravated while exercising.
Faced with the combined COPD-PAH threat, the Dutch team explored the potential benefit of treating at-risk chronic obstructive pulmonary disease patients with sildenafil both while at rest and during exercise. The drug works by shifting the activity of an enzyme called phosphodiesterase, reducing arterial blood pressure by dilating the smooth muscle of blood vessels that line the lungs. As these vessels expand, blood flow increases, the researchers explained.
The study authors focused on 12 patients who had been diagnosed with chronic obstructive pulmonary disease and were suspected of having PAH. Throughout the study, right heart blood pressure was tracked among all 12 patients by inserting a thin plastic tube into the pulmonary artery -- a procedure known as cardiac catheterization. Cardiac blood pressure was measured at rest and just after all the patients cycled for three minutes.
Then, the study participants were given 50 milligrams of oral sildenafil; 45 minutes later, resting and post-exercise blood pressure readings were taken again.
Holverda and his colleagues found that half the patients had PAH. But, both non-PAH and PAH patients experienced significant cardiac blood pressure increases when exercising.
Sildenafil appeared to control such increases after exercise, reigning in pulmonary blood pressure to markedly lower levels -- higher than at rest, but lower than non-medicated post-exercise readings. And, the non-PAH patients appeared to experience pulmonary blood pressure reductions after taking the drug, both while resting and exercising.
The authors concluded that the drug may help COPD patients -- whether they have developed PAH or not -- quickly control their pulmonary blood pressure in some situations.
Dr. Bartolome R. Celli, chief of pulmonary care at St. Elizabeth's Medical Center in Boston, applauded the Dutch study but called for more research.
"Pulmonary arterial pressure -- when it is elevated -- is a poor prognostic sign and reducing its levels should be of help," he said. "However, more testing is needed to see if those changes in pulmonary arterial pressure are translated into better clinical outcomes and not into any unwanted side effects."
Could a widely used treatment for depression be a remedy for osteoporosis?
Researchers have discovered that the drug Prozac also increases bone mass, at least in adult mice.
"Treating animals for six weeks with Prozac resulted in an increase in trabecular bone mass," said study lead author Ricardo Battaglino, assistant member of the staff in the department of cytokine biology at the Forsyth Institute in Boston. "It was a pretty significant 60 percent increase."
Trabecular bone is one of two main types of bone and makes up most of the spongy interior of the majority of bones.
Although it's way too early to advocate popping Prozac to reverse or stop bone loss, experts say it's a tantalizing lead for future research.
"For several reasons, people need to be cautious because fluoxetine [the generic name for Prozac] has central nervous system effects," said Dr. Grant Mitchell, chief of psychiatry at Northern Westchester Hospital Center in Mount Kisco, N.Y. "But it is interesting that current treatments for bone loss in osteoporosis do not take this approach, so the idea that we could at some point have another approach to reducing bone loss or even rebuilding new bone is actually exciting. Having more options would be great."
The study, which was funded by the U.S. National Institute of Dental and Craniofacial Research, is expected to be published in an upcoming issue of the Journal of Cellular Biochemistry.
Previous research, some of it by the same team, had found that serotonin receptors were commonly expressed on the surface of bone cells. Serotonin receptors govern the entry of serotonin -- a molecule that helps transmit signals between neurons and is implicated in anxiety and depression -- into cells.
Prozac is a member of a group of antidepressants called "selective serotonin reuptake inhibitors" (SSRIs) that act on this receptor.
The fact that these receptors populated bone cells "was surprising for us," Battaglino said, "because we were taking bone cells and serotonin, two molecules that apparently didn't have much to do with each other."
The next question was whether Prozac, which has an effect on serotonin, also exerted an influence on bone cells and, ultimately, bone mass.
For this study, laboratory mice were treated with Prozac for six weeks. The investigators were specifically interested in seeing if the drug stimulated new bone formation under normal conditions and if it blocked bone loss caused by inflammation or by loss of estrogen after taking out the ovaries.
Prozac both spurred the formation of new bone under normal conditions and reversed overall bone loss triggered by inflammation.
The drug was administered both systemically (like taking a pill) and locally (directly to the bone), and the effects were observed with both delivery methods, the researchers reported.
"They developed a way to deliver locally to the bone, which makes more sense," Mitchell pointed out. "The idea there would be to avoid the [potential] brain effects."
Oddly, a prior study using Prozac found that the drug actually hindered bone growth. The discrepancy may have been due to the way bone mass or density was measured and also to the fact that it involved children, not adults, Battaglino said.
In the new study, Prozac was not effective in female mice without circulating estrogen (i.e. after their ovaries had been removed). In those cases, Prozac "did not prevent bone loss associated with estrogen deficiency," Mitchell said. "It looks like, to be effective in relation to bone loss, Prozac needs to be in the presence of estrogen." This has implications for women moving into menopause who lose estrogen and have an increased risk of osteoporosis, he said.
The findings need to be replicated and, of course, tried in humans, but, given the number of people taking Prozac, the implications could be enormous.
"Fluoxetine is one of the most widely prescribed psychoactive drugs in this country and most likely the world, and it's been like that for at least 15 or 20 years," Battaglino said. "From the public health point of view, this would be pretty relevant."
The jury is still out on whether other SSRIs -- such as Celexa, Paxil and Zoloft -- might have the same effect on bone, Battaglino added, since similar tests on those drugs haven't yet been performed.
"This could be a class effect for SSRIs," he said. "However, it is known that in addition to blocking the serotonin transporter, Prozac can target other molecules -- for instance, some nicotinic acetylcholine receptors and even some serotonin receptors. So, this effect could be specific for Prozac. The experiments will have to be done to answer the question."
Cola may not be so sweet for women's bones, according to new research that suggests the beverage boosts osteoporosis risk.
"Among women, cola beverages were associated with lower bone mineral density," said lead researcher Katherine Tucker, director of the Epidemiology and Dietary Assessment Program at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.
There was a pretty clear dose-response, Tucker added. "Women who drink cola daily had lower bone mineral density than those who drink it only once a week," she said. "If you are worried about osteoporosis, it is probably a good idea to switch to another beverage or to limit your cola to occasional use."
The report was published in the October issue of the American Journal of Clinical Nutrition.
About 55 percent of Americans, mostly women, are at risk for developing osteoporosis, according to the National Osteoporosis Foundation.
In the study, Tucker's team collected data on more than 2,500 participants in the Framingham Osteoporosis Study, averaging just below 60 years of age. The researchers looked at bone mineral density at three different hip sites, as well as the spine.
They found that in women, drinking cola was associated with lower bone mineral density at all three hip sites, regardless of age, menopause, total calcium and vitamin D intake, or smoking or drinking alcohol. Women reported drinking an average of five carbonated drinks a week, four of which were cola.
Bone density among women who drank cola daily was almost 4 percent less, compared with women who didn't drink cola, Tucker said. "This is quite significant when you are talking about the density of the skeleton," she said.
Cola intake was not associated with lower bone mineral density in men. The findings were similar for diet cola, but weaker for decaffeinated cola, the researchers reported.
The reason for cola's effect on bone density may have to do with caffeine, Tucker said. "Caffeine is known to be associated with the risk of lower bone mineral density," she said. "But we found the same thing with decaffeinated colas."
Another explanation may have to do with phosphoric acid in cola, which can cause leeching of calcium from bones to help neutralize the acid, Tucker said.
One expert agrees that women should reduce the amount of cola they drink.
"I would expect this finding," said Dr. Mone Zaidi, director of the Mount Sinai Bone Program at Mount Sinai School of Medicine, in New York City. "It's probably a caffeine-related problem."
Women should limit their caffeine intake, Zaidi said. "Caffeine interferes with calcium absorption, which results in less bone formation," he said.
This can be a problem for younger women who never develop peak bone density, Zaidi noted. "Younger women who have a lot of coke will not form bone to an extent their peers would; so, years later, in menopause, they are going to be disadvantaged," he said.
Propecia Increases Hair Weight And Quality, Improves Scalp Coverage: Presented at ADV
AMSTERDAM, THE NETHERLANDS -- September 29,1999 -- The first-ever pill for male hair loss holds new promise for millions of men, following the results of a new study.
The treatment, Propecia (finasteride 1mg) has been proven to significantly increase hair weight and improve hair quality - making hairs thicker and longer in addition to increasing their number. This improvement in hair quality is good news for men who are concerned about their hair loss because improved hair quality provides improved scalp coverage.
Dr. Vera Price, of the Department of Dermatology, University of California, San Francisco, CA, presented findings from the Hair Weight Study for the first time today at the 8th European Academy of Dermatology and Venereology meeting, in Amsterdam, The Netherlands.
Results from a study involving 66 men taking either one Propecia tablet daily or placebo showed that after 96 weeks of treatment, Propecia increased hair growth on the scalp by improving the weight of hair.
Furthermore, the beneficial effects of Propecia continued throughout the two-year study period. The difference in total scalp hair coverage between the men taking Propecia and those taking placebo became greater as the study progressed - that is, men taking Propecia continued to grow more hair, thicker hair and longer hair, while those taking placebo were gradually losing hair.
The net improvement in hair weight between men treated with Propecia compared to those treated with placebo was 35.8 percent (P<0.001) after 96 weeks.
"The increase in hair weight produced by treatment with finasteride 1mg as demonstrated in this latest study, reflects the beneficial effects of the drug on the key aspects of hair quality. These aspects include increased hair number, shown in previous studies as well, and additionally improved hair thickness and hair length," said Dr. Price.
Hair weight is a quantitative, reliable measure of hair growth and provides an integrated measure of changes in hair growth rate and total hair mass (length, hair thickness and hair number). Hair growth rate and total hair mass determine hair quality, and improved hair quality provides improved coverage of the scalp. Therefore, hair weight is an accurate way to measure the cosmetic benefits of treatment for male pattern hair loss.
By using phototrichogram methodology it has been shown that Propecia actually stimulates resting hair follicles to grow, thereby increasing the total number of growing hairs at any one time (Van Neste, et al.). These additional growing hairs observed in treated patients have now been shown to grow longer and thicker, signifying an improvement in hair quality and an improvement in scalp coverage.
Evidence of the cosmetic benefits of Propecia can be fully substantiated by worldwide clinical trial results. Propecia after two years of treatment has been shown to prevent further hair loss in five out of six men treated (83 percent, v. 28 percent placebo) and to re-grow hair that visibly increased scalp coverage in two out of three men (66 percent, v. 7 percent placebo).
The world's first hair loss pill for men is only available by prescription from a doctor and has proven to be well tolerated in clinical trials. Drug-related adverse events occurred in less than 2 percent of men taking Propecia. These side effects went away in all men who discontinued therapy and also disappeared in most men who chose to continue taking Propecia.
Propecia was first launched in the United States in 1997. It is currently available in most European countries and 22 other countries worldwide.
Propecia is administered as a 1mg oral tablet once daily. It is not indicated for use in women or children. It is a product of Merck, Sharp & Dohme.
The average male has four to eight spontaneous erections every night while he sleeps. They usually occur during the REM stage, when dreaming is most common.
When a doctor wants to know whether a patient's difficulty achieving an erection is due to physical or mental reasons, one way to find out is to fit the patient's penis with a sensor and see whether or not the patient's dream erections are working properly. If not, the problem is probably physical.
History of Viagra
Viagra was initially developed a heart condition called angina, during the testing period for this drug it was found to give an erection to men. The drug was patented in 1996, approved in 1998 making viagra the first official drug to treat erection problems and being made available for sale later that year. The success of this drug is over whelming. You can get viagra on perscription from your doctors or on numerous websites after consultation (a mere questionaire). The fact is, it has improved the sex lives of millions men and women around the world. Annual sales of Viagra in the period 1999 - 2001 exceeded .750,000,000.
It was first thought that Viagra would lead to a drop in the market for traditional remedies which came from specific body parts of endangered species. This is highly unlikely as the traditional remedies is a treatment not just for erectile dificinency e.g. the Rhinoceros horns are used for high fever. Further on it is unclear that natural remedies will be able to compete with Viagra, due to its aphrodisiac properties.
Since Viagra's release, there has been an increase in 'fake viargra' being sold on the interne which looks like viagra (blue diamond pill) will the companies name, Pfizer engraved on it. These have proven to be dangerous and you must be careful where you buy viagra. Check out our purchasing viagra guide.
Pfizer's worldwide patents on Viagra will expire in 2011 - 2013. The UK patent held by Pfizer on the use of Viagra as treatment of impotence has been invalidated in 2000 because of obviousness; this decision was upheld on appeal in 2002.
http://www.lidrock.com/viagra.htm
Viagra and the Mountains
Researchers Say the Drug May Help Performance at High Altitude, Help Soldiers Fight in Afghanistan
As the commercials continually remind us: Viagra is all about performance.
Now it turns out, that's not just referring to in the bedroom.
Researchers say the drug, approved for erectile dysfunction, could eventually help some athletes train at high altitudes and soldiers fight in the mountains of Afghanistan.
In a study at Stanford University, some volunteers riding stationary bicycles and breathing through masks to simulate the low oxygen conditions found at 12,700 feet, improved their times for six kilometers by an average of 39 percent after taking Viagra.
The drug, which became an instant blockbuster for Pfizer in 1998, works by causing blood vessels to relax - not only in the penis but in the lungs.
Last year, the company won approval for the drug, also known as sildenafil, to treat a medical condition called pulmonary hypertension, or high fluid pressure in the lungs. Pulmonary hypertension is also one of the effects of exercising in oxygen-poor environments such as high altitudes.
"It provides a pretty clear advantage to some people," said Annie Friedlander, the senior author of the study, which appears in the Journal of Applied Physiology.
It does not help everyone. Only four of the 10 riders saw their times improve - 10 minutes, 48 seconds with Viagra compared to 15 minutes when they took a placebo.
Researchers are not certain why only some volunteers responded to the drug, but they noticed that they were the ones whose times had suffered the most at high altitudes. Viagra, it seems, allowed them to make up the performance they had lost.
None of the riders saw any improvement from the drug at sea level, and none reported an erection during the trials.
The next step: The U.S. military plans to test Viagra, at high altitude, on about a dozen soldiers later this summer.
http://abcnews.go.com/Health/story?id=2111548
Women can benefit from Viagra
Viagra may help some women
Women can benefit from taking the impotence drug Viagra, scientists have claimed.
Research by a team from the University of Boston has found that the drug can benefit women who have had a hysterectomy or who have gone through the menopause.
In both cases, women experience a loss of production of female hormones that can lead to sexual problems, such as loss of sensation and lubrication.
Dr Jennifer Berman tested the drug on 17 women who had either had a hysterectomy or gone through the menopause.
Each woman got either Viagra or a dummy pill, and three months later the women who got Viagra were switched to a placebo and the women who had been given sugar pills got Viagra.
Dr Berman and the patients did not know which woman got which pill until the end of the study.
Viagra, whose technical name is sildenafil, works by increasing the effects of nitric oxide, a common body chemical, which in turn gets more blood flowing into the genitals.
Dr Berman, who will present her findings to a meeting of the American Urological Association, said: "Sildenafil did appear to significantly increase blood flow and pH and pH is an indicator of lubrication."
"Subjectively, with regard to lubrication, sensitivity, the ability to have orgasm, and satisfaction, the women noted a significant difference."
Emotional problems
Dr Berman has carried out another study at Boston University with 48 women, aged 22 to 71.
While not so carefully controlled - the women all got Viagra and knew it - there was a statistically significant difference.
She said: "It does appear to be Viagra because there are physiological changes that can't be faked."
However, Viagra failed to work for women in the second study who had psychological problems with sex.
These included poor body image, a history of sexual abuse, or marital trouble.
Dr Berman said: "Those women don't respond to Viagra or any drug.
"Although there are physiological, medical reasons why women have sexual complaints, there are emotional and relational consequences to sexual dysfunction that are relevant to women."
She added that it was more difficult to tell if a woman had sexual problems.
"While men can define their sexual function in terms of rigidity, for women it doesn't work that way," she said.
Pfizer, the manufacturers of Viagra, say that seven million prescriptions have been written for the drug worldwide since its launch last year.
A spray could have a faster effect than a pill
Impotent men could benefit from Viagra in five to 10 minutes instead of up to an hour by taking the drug through the nose, researchers say.
They have developed a nasal spray form of the anti-impotence drug that they say works up to 12 times faster than the average pill.
They also said that the faster action would prevent users taking a double dose of the drug, which could lead to harmful side effects.
Nasal delivery
Professor Anwar Hussein, a researcher at the University of Kentucky College of Pharmacy, said he and Professor Lewis Dittert developed the nasal spray.
He said they have patented the technology and want to license it to Pfizer.
"Sometimes patients taking Viagra are embarrassed because they wait an hour or longer and still there's no effect, especially if they've taken the pill with meals," Professor Hussein.
Frustrated patients then sometimes take another pill in an attempt to speed the effect. This creates the risk of adverse side effects, Professor Hussein said.
Since Viagra went on the market last year, approximately 130 men have been reported to have died after taking it.
Key
"The key" to the nasal spray "was to find how to make Viagra very water soluble so the dissolved drug can be used through the nose", Professor Hussein said.
They tested nasal drops in rats and found that it took effect "within five to 10 minutes", Professor Hussein said.
"Our version will be so quick and convenient to use and would definitely be more popular than the pills, which just take too long to work."
He said he wants Pfizer to take up the licence and start tests of the spray on humans.
Romance
But Pfizer, the company that makes Viagra, said that it had not received complaints about the drug's speed of action.
Andy Burrows, a spokesman for the company, said the researchers were operating entirely independently of the company.
He said the company had no plans to develop a faster working form of the drug.
Although Viagra's licence says that users should allow up to an hour for it to take effect, performance depended on the individual and could be as fast as 20 minutes, he said.
But the company was working on a wafer form which, although no faster than the pills, would be easier to ingest, he said.
"You have to compare what Viagra offers with what was on offer before. That is, an injection in the penis or a pellet that you have to stick into the urethra and massage for 10 minutes," he said.
"Then instantly you get the sexual stimulation no matter what, without the romantic side."
"With Viagra you may have to plan ahead a little bit but it creates a much more natural response than anything else that's around."
"You have to compare it with what there was before," he said.
He added that it was unusual but not unheard of for researchers to set to work on a company's product independently.
However, when it did happen, it was usually when the patent on a product was about to expire.
The UK government, which has placed a temporary ban on NHS prescription of Viagra, is due to announce guidelines on its use next week.
The findings come from a study led by Jennifer R. Berman, MD and Laura A. Berman PhD.
Pfizer Inc (maker of Viagra) funded the study which monitored 200 postmenopausal women with FSAD (female sexual arousal disorder).
100 women received Viagra while the other half were on a placebo. More women on Viagra (than the placebo) reported better sexual (more sexual) satisfaction. Some of the women on the placebo also reported an improvement (lower number than those on Viagra).
All the women who had hypoactive sexual desire disorder (HSDD) as well as FSAD reported no improvement at all.
The most common problem for women with FSAD is genital blood flow (which Viagra seems to be able to help). Women with HSDD have underlying emotional or relationship problems which lead to a reduction in sexual desire.
'Unresolved emotional or relational issues should be addressed before beginning medical therapies,' Berman her colleagues said (December issue of The Journal of Urology).
Those in the study included women who were postmenopausal (or had had a hysterectomy), aged from 30-71 (average age 51).
Two questions (asked after the women had taken the Viagra of Placebo) the team focussed on were:
1. After taking the study medication, the sensation/feeling in my genital (vagina, labia, clitoris) area during intercourse or stimulation seemed to be: (a) more than before, (b) less than before, or (c) unchanged.
2. After taking the study medication, intercourse and/or foreplay was (a) pleasant and satisfying; better than before taking the study medication; (b) unpleasant; worse than before the study medication; (c) unchanged; no difference; or (d) pleasant but still not like it used to be or I would like it to be.
Regarding Question 1 the results were:
Placebo patients: 44% reported an improvement
Viagra Patients: 57% reported an improvement
Regarding Question 2 the results were:
Placebo patients: 26% reported an improvement
Viagra patients: 42% reported an improvement
However, of the patients (on Viagra) with sexual arousal disorder who did not have HSDD 68% reported an improvement on the first question (eight times more than women without HSDD who were on the placebo).
In addition, of the patients (on Viagra) with sexual arousal disorder who did not have HSDD, 50% said there was an improvement in question 2 (11 times more than the non-HSDD women on the placebo).
The authors also said that women who respond to Viagra may need to have normal levels of oestrogen and testosterone. For many postmenopausal women, that may mean menopausal replacement therapy. In the present study, the women had normal hormone levels or were receiving menopausal replacement therapy.
ROTTERDAM, Netherlands, Oct. 2 (UPI) -- Dutch scientists say they have found a drug usually prescribed for erectile dysfunction in men increases the sexual function of prostate cancer survivors.
Prostate cancer is the most commonly diagnosed cancer in men. But after treatment, some patients report trouble achieving an erection sufficient for sexual activity -- a medical condition called erectile dysfunction or ED. In the Dutch study, physicians wanted to test whether the drug Tadalafil, which sells under the brand name Cialis, would help prostate cancer survivors with ED who were treated with three-dimensional conformal radiation therapy.
In what is believed the first randomized trial of its type, successful intercourse was reported in 48 percent of the survivors who took Tadalafil versus 9 percent of the men who were given placebo. There was also a reported improvement of the quality of erections in 67 percent of the patients, versus 20 percent of the placebo group.
The research conducted at the Erasmus MC-Daniel den Hoed Cancer Center in Rotterdam is detailed in the International Journal of Radiation Oncology Biology Physics.
Study: Erectile dysfunction drug relieves symptoms of Raynaud's
MEDPAGE TODAY
Little Blue Pill May Put Brakes on Some Heart Disease
Many men use Viagra (sildenafil) to speed up their sex lives. Now it seems that if some research pans out the little blue pill may also wind up slowing down some forms of heart disease.
NEW YORK - Viagra (sildenafil) relieves the symptoms and improves the circulation of patients with Raynaud's phenomenon that does no response to conventional therapy, German investigators report. In patients with ulcers on their fingers or toes, the treatment leads to healing.
Viagra, developed to treat of male erectile dysfunction, is a phosphodiesterase (PDE)-5 inhibitor that affects very small blood vessels. Studies have shown it improves circulation in other conditions, such as coronary artery disease.
Raynaud's phenomenon is characterized by spasms in the small blood vessels of the hands and feet in response to cold or stress, resulting in poor circulation and pain. The disorder can also lead to ulceration or tissue death in the toes and fingers.
http://msnbc.msn.com/id/9967683/
We have received both parts of the shipment, and my husband and I are very
satisfied with the product.
